Opening College Football Week 4 Odds, Spreads and Early Predictions
- Week 4 of the College Football season begins in earnest Friday night with Virginia hosting Wake Forest
- The top matchup of the week has #7 Texas A&M and #16 Arkansas meeting in Arlington, Texas
- The full list of opening Week 4 odds and lines can be found below
After Alabama held off Florida 31-29 in thriller on Saturday, there is another key SEC game headlining the Week 4 schedule.
#7 Texas A&M and #16 Arkansas – both 3-0 – meet at AT&T Stadium in Arlington, Texas on Saturday. While Arkansas is technically the home team at Jerry World – Dallas Cowboys owner Jerry Jones played for the Razorbacks – the home-state Aggies figure to have a big following.
Texas A&M is a touchdown favorite.
Another neutral-site game pits #12 Notre Dame (3-0) against #18 Wisconsin (1-1) at Soldier Field in Chicago. The Badgers had a week off to get ready for the Fighting Irish.
Here is a look at all the Week 4 odds:
College Football Week 4 Opening Odds
| Game Time (Eastern) | Team | Spread | Moneyline |
|---|---|---|---|
| Friday, Sept. 24 | Wake Forest | +4.5 (-110) | OFF |
| 7:00 p.m. | Virginia | -4.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Friday, Sept. 24 | Liberty | -7 (+100) | OFF |
| 8:00 p.m. | Syracuse | +7 (-120 | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Friday, Sept. 24 | UNLV | +28.5 (-110) | OFF |
| 10:00 p.m. | Fresno State | -28.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Missouri | -1.5 (-110) | OFF |
| 12:00 p.m. | Boston College | +1.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Bowling Green | +30 (-110) | OFF |
| 12:00 p.m. | Minnesota | -30 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | LSU | -4 (-110) | OFF |
| 12:00 p.m. | Mississippi State | +4 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Ohio | +15 (-110) | OFF |
| 12:00 p.m. | Northwestern | -15 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | SMU | +10.5 (-110) | OFF |
| 12:00 p.m. | TCU | -10.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Texas Tech | +11 (-110) | OFF |
| 12:00 p.m. | Texas | -11 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Georgia | -32.5 (-110) | OFF |
| 12:00 p.m. | Vanderbilt | +32.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Notre Dame | +5 (-110) | OFF |
| 12:00 p.m. | Wisconsin | -5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Massachusetts | +35 (-110) | OFF |
| 1:00 p.m. | Coastal Carolina | -35 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Washington State | +13.5 (-110) | OFF |
| 2:30 p.m. | Utah | -13.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Louisville | -2.5 (-110) | OFF |
| 3:30 p.m. | Florida State | +2.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Colorado State | +23 (-110) | OFF |
| 3:30 p.m. | Iowa | -23 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Kent State | +14.5 (-110) | OFF |
| 3:30 p.m. | Maryland | -14.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | UTSA | +5.5 (-110) | OFF |
| 3:30 p.m. | Memphis | -5.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Rutgers | +18.5 (-110) | OFF |
| 3:30 p.m. | Michigan | -18.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Illinois | +10.5 (-110) | OFF |
| 3:30 p.m. | Purdue | -10.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Clemson | -12 (-110) | OFF |
| 3:30 p.m. | NC State | +12 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Texas A&M | -6 (-110) | OFF |
| 3:30 p.m. | Arkansas | +6 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Iowa State | -5.5 (-110) | OFF |
| 3:30 p.m. | Baylor | +5.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Georgia State | +25.5 (-110) | OFF |
| 4:00 p.m. | Auburn | -25.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Kansas | +13 (-110) | OFF |
| 4:00 p.m. | Duke | -13 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Arkansas State | +13.5 (-110) | OFF |
| 5:00 p.m. | Tulsa | -13.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | UCLA | -4.5 (-110) | OFF |
| 6:00 p.m. | Stanford | +4.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Tennessee | +19.5 (-110) | OFF |
| 7:00 p.m. | Florida | -19.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Navy | +20.5 (-110) | OFF |
| 7:00 p.m. | Houston | -20.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Nebraska | +4 (-110) | OFF |
| 7:00 p.m. | Michigan State | -4 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Kansas State | +8.5 (-110) | OFF |
| 7:00 p.m. | Oklahoma State | -8.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Kentucky | -5.5 (-110) | OFF |
| 7:00 p.m. | South Carolina | +5.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Southern Miss | +43.5 (-110) | OFF |
| 7:30 p.m. | Alabama | -43.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Akron | +49 (-110) | OFF |
| 7:30 p.m. | Ohio State | -49 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | West Virginia | +15.5 (-110) | OFF |
| 7:30 p.m. | Oklahoma | -15.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Sunday, Sept. 25 | North Carolina | -12 (-110) | OFF |
| 7:30 p.m. | Georgia Tech | +12 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | UAB | +4 (-110) | OFF |
| 8:00 p.m. | Tulane | -4 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Indiana | -10 (-110) | OFF |
| 8:00 p.m. | Western Kentucky | +10 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | California | +8.5 (-110) | OFF |
| 9:30 p.m. | Washington | -8.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | South Florida | +22.5 (-110) | OFF |
| 10:15 p.m. | BYU | -22.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Colorado | +14 (-110) | OFF |
| 10:30 p.m. | Arizona State | -14 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Arizona | +28 (-110) | OFF |
| 10:30 p.m. | Oregon | -28 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| Saturday, Sept. 25 | Oregon State | +12.5 (-110) | OFF |
| 10:30 p.m. | USC | -12.5 (-110) | OFF |
Odds as of September 18th at DraftKings.
Aggies, Hogs Meet as Unbeatens
Texas A&M tuned up for its SEC opener with a 34-0 blanking of New Mexico on Saturday to open a season 3-0 for the first time since 2016.
Zach Calzada threw for 275 yards and three touchdowns in his first career start. Calzada was thrust into the job the previous week against Colorado when Haynes King broke his right leg on Texas A&M’s second possession.
Zach Calzada brought Kyle Field to its feet with this 70-yard TD throw to Demond Demas in the first quarter. #GigEm pic.twitter.com/adYH2VmuxB
— Jack Allen (@JackAllenKXXV) September 18, 2021
The Aggies defense held Terry Wilson, a transfer from Kentucky, to 33 yards passing.
Arkansas notched an easy 45-10 home victory over Georgia Southern on Saturday. KJ Jefferson passed for a career-high 366 yards and tied a career high with three touchdowns.
Arkansas put the game away on a 91-yard pass from Jefferson to Treylon Burks with 11:18 left in the third quarter. It was Jefferson’s final touchdown pass and gave the Razorbacks a 38-10 lead.
TREYLON BURKS 91-YARD HOUSE CALL 💨 @razorbackfb pic.twitter.com/E3fQ9cJA2z
— SEC Network (@SECNetwork) September 18, 2021
Texas A&M was expected to be good this season, Arkansas not so much. However, the Razorbacks look legit and should be able to get under the six-point spread if not win the game outright.
ND, Badgers in Midwest Clash
Notre Dame has not looked sharp in winning its first three games, including Saturday when it downed Purdue 27-13 for its 26th straight win at home.
Kyren Williams was the difference maker as he had two long touchdowns, including a 51-yard run with 6:05 remaining that sealed the victory. Williams also caught a 39-yard TD pass from Jack Coan while rushing for 86 yards on 11 carries.
Kyren Williams takes it 51 yards for a Notre Dame TD 😤
(via @NDonNBC)pic.twitter.com/HqZhS4sXIN
— Bleacher Report (@BleacherReport) September 18, 2021
Coan was sacked four times and completed just 15 of 31 passes while finishing with 223 yards and two TDs. The victory was the 105th in Brian Kelly’s 12-year career at Notre Dame, tying him with Knute Rockne as the winningest coach in school history.
After losing to Penn State 16-10 at home to start the season, Wisconsin bounced back to thump Eastern Michigan 34-7 before having its bye week.
This will be an emotional game for Coan, who transferred from Wisconsin after last season. However, the well-rested Badgers should cover the five-point spread against the inconsistent Fighting Irish.
Georgia Looks Undervalued
#2 Georgia opened a 32-point home favorite over Vanderbilt, which is a substantial number for an SEC games.
Quarterback JT Daniels returned to the lineup Saturday and led Georgia (3-0) to a 40-13 win over South Carolina in Athens. He had been sidelined the previous week with an oblique injury.
Daniels completed 23 of 31 for 303 yards, including touchdown passes of 43 yards to Jermaine Burton, 38 yards to freshman Adonai Mitchell and 4 yards to James Cook.
JT Daniels first game back from injury:
🦴 23-31
🦴 303 YDS
🦴 3 TD
🦴 1 INTQB1 back like he never left pic.twitter.com/8q6bN8ODLU
— Bleacher Report CFB (@BR_CFB) September 19, 2021
Vanderbilt (1-2) lost to Stanford 41-23 at home Saturday. The Commodores make the final margin look closer by scoring a touchdown on the game’s final play.
Georgia is clearly 32 points better than Vanderbilt, so look for that line to up between now and Saturday.
John Perrotto has been covering and writing about sports for various outlets for over 40 years. His work has appeared in the likes of USA TODAY, ESPN.com, SI.com, Forbes.com, The Associated Press, Baseball Digest, and more. John is based out of Beaver Falls, PA.
