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Chiefs vs 49ers Prop Picks – Best Player Prop Bets for Week 7

Michael Harrison

by Michael Harrison in NFL Football

Updated Mar 16, 2023 · 12:36 PM PDT

San Francisco 49ers wide receiver Deebo Samuel is tackled
Oct 3, 2022; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) is tackled by Los Angeles Rams linebacker Ernest Jones (53) during the third quarter at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports
  • See the latest props for the Chiefs vs 49ers contest on Sunday, October 23, 4:25 pm ET in Week 7
  • Get the odds for Patrick Mahomes, Deebo Samuel and more players in the Chiefs vs 49ers prop bets
  • Chiefs vs 49ers props can be found below, along with analysis and predictions for a Sunday afternoon tilt

Two teams with Super Bowl aspirations square off Sunday afternoon with the Chiefs (4-2) battling the 49ers (3-3). Player props are available for this rematch of SB LIV, which was won by Kansas City. Both teams see their Super Bowl odds in the top-five currently.

The 49ers made a blockbuster move on Thursday, acquiring star running back Christian McCaffrey from the Panthers in exchange for four draft picks. The Niners are unsure if he’ll suit up or if he’ll take the week to learn the playbook.

Let’s dive into the top Week 7 player props to make for your Chiefs vs 49ers picks in NFL Week 7.

Chiefs vs 49ers Props

Quarterbacks Completions Passing Yards Passing TD
Patrick Mahomes (KC) 25.5 (Ov -135 | Un +105) 281.5 (Ov -115 | Un -115) 2.5 (Ov +150 | Un -205)
Jimmy Garoppolo (SF) 22.5 (Ov -135 | Un +100) 251.5 (Ov -115 | Un -115) 1.5 (Ov -110 | Un -120)
Running Backs Attempts Rush Yards Rush + Rec Yards
Clyde Edwards-Helaire (KC) 9.5 (Ov -120 | Un -110) 35.5 (Ov -110 | Un -120) 53.5 (Ov -110 | Un -120)
Deebo Samuel (SF) N/A 15.5 (Ov -115 | Un -115) N/A
Wide Receivers + Tight Ends Receptions Receiving Yards Longest Reception
Travis Kelce (KC) 6.5 (Ov -105 | Un -125) 71.5 (Ov -115 | Un -115) 22.5 (Ov -105 | Un -125)
JuJu Smith-Schuster (KC) 4.5 (Ov -120 | Un -110) 48.5 (Ov -110 | Un -120) 18.5 (Ov -125 | Un -105)
Marquez Valdes-Scantling (KC) 3.5 (Ov +135 | Un -185) 37.5 (Ov -115 | Un -115) 19.5 (Ov -110 | Un -120)
Mecole Hardman (KC) 2.5 (Ov -125 | Un -110) 27.5 (Ov -115 | Un -115) 15.5 (Ov -110 | Un -120)
Deebo Samuel (SF) 5.5 (Ov +115 | Un -155) 58.5 (Ov -115 | Un -115) 21.5 (Ov -120 | Un -110)
George Kittle (SF) 4.5 (Ov -120 | Un -110) 48.5 (Ov -115 | Un -115) 19.5 (Ov -110 | Un -120)
Brandon Aiyuk (SF) 4.5 (Ov -105 | Un -125) 54.5 (Ov -115 | Un -115) 21.5 (Ov -120 | Un -110)
Jauan Jennings (SF) 1.5 (Ov -110 | Un -120) 15.5 (Ov -115 | Un -115) 11.5 (Ov -120 | Un -110)

Odds as of Oct. 22 at DraftKings Sportsbook. Get the DraftKings promo code here to make your SNF prop bets.

Patrick Mahomes is lined at 2.5 passing touchdowns in the odds above, while Jimmy Garoppolo is 1.5 TD passes. Clyde Edwards-Helaire has the highest rushing total set at 35.5, while Travis Kelce has the highest receiving total prop at 71.5 yards.

Kickoff is set for 4:25 pm ET.  This contest carries a 48.5-point total with the Chiefs favored by 2.5 points. It’s expected to be sunny with wind gusts reaching 18 miles per hour.

Pick #1: Deebo Samuel Over 58.5 Receiving Yards

This season, the Kansas City Chiefs have allowed the sixth-highest passing yards per game in the NFL. With that in mind, we look at the line of Deebo Samuel’s 58.5 receiving yards and think he’ll hit the over.

In three of his last four contests, Samuel has racked up at least 73 receiving yards (including a 115-yard game). He’s a threat to catch the ball and take it to the house with a ton of YAC at any time, which he could very well do against a Chiefs D that’s allowed a lot of yards.

  • Prop Pick: Deebo Samuel Over 58.5 Receiving Yards (-115), 1 unit

Kansas City vs San Francisco Touchdown Props

Player Odds to Score 1st TD Odds to Score Anytime TD
Travis Kelce (KC) +650 -120
Deebo Samuel (SF) +650 -110
Jeff Wilson Jr. (SF) +650 -110
Christian McCaffrey (SF) +750 +110
Clyde Edwards-Helaire (KC) +850 +120
Brandon Aiyuk (SF) +1100 +170
George Kittle (SF) +1200 +185
JuJu Smith-Schuster (KC) +1200 +185
Marquez Valdes-Scantling (KC) +1400 +225
Mecole Hardman (KC) +1900 +310
Jerick McKinnon (KC) +2200 +360
Patrick Mahomes (KC) +2500 +425
Skyy Moore (KC) +2800 +500
49ers D/ST +2800 +475
Chiefs D/ST +2800 +550
Isiah Pacheco (KC) +3000 +600
Jauan Jennings (SF) +3000 +475
Tevin Coleman (SF) +3500 +600
Jody Fortson (KC) +3500 +650
Noah Gray (KC) +3500 +650
Jimmy Garoppolo (SF) +4000 +650
Kyle Juszczyk (SF) +4000 +750

Travis Kelce is tied with Deebo Samuel and Jeff Wilson Jr. for the shortest odds to record the first TD. Kelce has the most touchdown catches (7) in the NFL.

Pick #2: Kelce Strikes First

Travis Kelce is coming off another typical monster week, as he racked up 108 yards on eight catches against Buffalo. Remarkably, he didn’t find the end zone, which was only the second time that’s happened in his last twelve contests (including postseason).

He’ll be hungry to find paydirt again, as he had a whopping four TD’s in his previous game. He’s scored a touchdown in two of three career games against the Niners (including the Super Bowl).

As for an anytime TD scorer, why not pair up our previous wager of over 58.5 yards for Deebo Samuel with an anytime touchdown as well? He’s recorded a touchdown in two of his last three games and has one in three total contests this campaign.

Touchdown Prop Picks:

  • Travis Kelce First TD (+650), 1 unit
  • Deebo Samuel Anytime TD (-110), 1 unit
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