Tampa Bay Buccaneers vs San Francisco 49ers Prediction, Odds, Spread for Week 14

• Tampa Bay visits San Francisco in Week 14 NFL action on Sunday, December 11th
• Tom Brady will make his 329th start while Brock Purdy will make his first-ever start
• Check out all the odds and our predictions for Tampa Bay Buccaneers vs San Francisco 49ers below

Tom Brady returns to his native west coast as the Tampa Bay Buccaneers battle the San Francisco 49ers in week 14 NFL action on Sunday.

Tampa Bay heads west after an epic 17-16 comeback victory over the New Orleans Saints on Monday night football.

While San Francisco has major concerns at the game’s most important position after Jimmy Garoppolo left last week’s victory in Miami with an ankle injury. Third-string rookie quarterback Brock Purdy will get the start on Sunday afternoon.

This week 14 showdown gets underway from Levi’s Stadium at 4:25 ET on Fox. Check out all the odds and our best bets for Tampa Bay Buccaneers vs San Francisco 49ers below.

Tampa Bay Buccaneers vs San Francisco 49ers Odds

Odds as of December 10th at BetMGM. Claim the BetMGM promo code for NFL betting. 

San Francisco enters this matchup as 3.5-point home favorites. While the total for Tampa Bay Buccaneers vs San Francisco 49ers game sits at just 37. Presently, bettors are all over the Buccaneers as 88% of bets placed with the spread are on the Bucs to cover.

Tampa Bay Buccaneers Betting Trends

Tampa Bay heads to San Francisco are a harrowing escape on Monday Night Football. Aided by head-scratching late-game mistakes by the Saints, Tom Brady did what he does best and led his team to the win on the final drive.

Although the Bucs sit at just 6-6 they are in the driver’s seat for yet another NFC South crown. However, overcoming the elite 49ers defense, on short rest, while playing on the road presents another interesting challenge for Tom Brady’s team.

Tom Brady is 45 years old. Still the GOAT. pic.twitter.com/BvrM4AoMeL

— Barstool Sports (@barstoolsports) December 6, 2022

Alarmingly, the Buccaneers will enter this one without four starters on the offensive line. Additionally, Leonard Fournette and Vita Vea both popped up on the injury report this week with foot injuries. Vea is crucial to everything Tampa runs on defense, and will be needed to slow down the potent 49ers rushing attack. Moreover, starting safeties Mike Edwards and Antoine Winfield Jr. remain questionable. Any way you slice it, this is a banged-up Tampa Bay Buccaneers football team.

Frighteningly, the Buccaneers have been an awful team for bettors to back this season. Todd Bowles’ charges are just 3-8-1 against the spread this season. On top of that, Tampa have failed to cover the spread in 7 straight games following an against the spread loss.

San Francisco 49ers Betting Trends

While the Buccaneers have been hampered by injuries as of late, the San Francisco 49ers were just starting to get healthy. Then, quarterback Jimmy Garoppolo was carted off with an ankle injury last week. Once thought of as one of the true NFC contenders, the injury to Garoppolo has sent the 49ers season into disarray.

In steps this year’s Mr. Irrelevant, former Iowa State quarterback Brock Purdy. Purdy threw for 210 yards and 2 touchdowns in relief of Garoppolo last week, and looked confident in the pocket throughout the game. While Purdy makes his first start on Sunday, Tom Brady will be making his 329th.

#49ers Brock Purdy was HYPED after his first career touchdown pass 😂 pic.twitter.com/gEitaGTeYR

— 𝙏𝙝𝙚𝙎𝙁𝙉𝙞𝙣𝙚𝙧𝙨 (@TheSFNiners) December 4, 2022

San Francisco’s top-ranked defense will have to do the heavy lifting in this one. Thankfully, DeMeco Ryans unit is more than up to the task. The 49ers rank first in the league in total defense, rushing defense, and scoring defense.

Fortunately, it appears all the 49ers key pieces will take the field in this one. As Christian McCaffrey, Deebo Samuel and Nick Bosa are all set to play. Additionally, San Francisco is 5-1 ATS in their last five games against teams with a losing record.

Tampa Bay Buccaneers vs San Francisco 49ers Betting Trends

As much as the headlines will portray this football game as Tom Brady going head to head with Brock Purdy, these teams’ defenses are some of the best in the league. The top-ranked 49ers defense will look to lead the way for their rookie quarterback. Tampa currently employs the 10th-ranked defense.

This season, these teams have combined to allow just over 34 points per game. Although it may not be the most glamorous bet, take the under here.

Pick: Tampa Bay Buccaneers vs San Francisco 49ers UNDER 37 (-110), Risk: 1 unit

2022 NFL Record: 9-8-1, +1 unit

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