Louisville vs Indiana Odds, Lines & Predictions (Saturday, Sep. 16)
- The 2-0 Louisville Cardinals are 10-point favorites against the 1-1 Indiana Hoosiers in their college football game slated for Saturday, September 16
- It’s only the third meeting between the two schools and the first since 1986
- Indiana is 2-0 straight up and against the spread in those two previous games
The Louisville Cardinals (2-0, 1-1 ATS) and Indiana Hoosiers (1-1, 2-0 ATS) are meeting on the football field for the first time in decades. And it appears it will also be their last meeting for quite some time.
Set to be the first of a three-game series between the two schools, news broke this week that the Hoosiers were paying the Cardinals $1.3 million to get out of the remaining two games.
Indiana has never lost to Louisville, but oddsmakers see that scenario changing. The unbeaten Cardinals are set as 10-point favorites. Indiana is 1-5 straight up in the school’s past six home games.
Let’s dive deeply into the Louisville vs Indiana odds and offer you our pick for this Week 3 college football game.
Louisville vs Indiana Odds
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| Louisville Cardinals | -370 | -10 (-110) | Over 50.5 (-110) |
| Indiana Hoosiers | +290 | +10 (-110) | Under 50.5 (-110) |
In the Louisville vs Indiana odds, the Cardinals are -370 moneyline favorites, giving them a 78.72% implied win probability. The total is set at 50.5 points.
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Odds as of Sept. 15 at BetMGM. Be sure to claim a BetMGM promo code to bet on Cardinals vs Hoosiers and other college football Week 3 action this week.
In previous meetings, both played at Indiana, the Hoosiers were 21-0 winners in 1986 and 41-28 victors in 1985. Both of those games were also played during Week 3 of the schedule.
Kentucky bettors can wager on the Cardinals in their home state at retail sports betting sites. Legal sports betting launched in the Bluegrass State on Sept. 7. All of the top Kentucky online sports betting sites will be launching on Sept. 28.
This contest is being played in Indiana, but at a neutral site – Lucas Oil Stadium , home to the NFL’s Indianapolis Colts. Kickoff for this game is set for 12:00pm ET on Saturday, September 16. The broadcast is being carried by the Big Ten Network.
Louisville vs Indiana Betting Splits
In the college football public betting splits, spread bettors are leaning Indiana’s way, while moneyline players are overwhelmingly backing Louisville. The underdog Hoosiers are pulling 65% of handle and 68% of bets in spread splits at +10. Indiana is 3-1 ATS over the past four games. Moneyline splits are giving 97% of handle and 92% of bets to the Cardinals at -370. Louisville is 8-2 SU through the last 10 games.
The under is the popular play on the total of 50.5 points. It’s garnering 69% of handle and 57% of bets. Five of Louisville’s last seven games went under. However, four of Indiana’s last six games hit on the over.
Louisville is set with a betting line of +15000 in the National Championship odds. Indiana is given odds of +12500 to win the Big Ten title.
Cardinals Displaying Explosive Offense
Under new coach Jeff Brohm, Louisville is flexing powerfully when in possession of the ball. The Cardinals are fourth in the nation in total offense (582.0 yards per game) and third in the country in rushing offense (285.5 YPG).
Cardinals RB Jawhar Jordan has gained 231 yards on 14 carries. That’s an amazing 16.5 yards per attempt. Wideout Jamari Thrash has already caught three touchdown passes.
Louisville put up 690 yards of offense while holding Murray State to just 166.
— Matt McGavic (@Matt_McGavic) September 8, 2023
Off to their best start since 2017, Louisville crushed Murray State 56-0 last week. In Week 1, the Cardinals rallied from a 15-point halftime deficit to beat Georgia Tech 39-34. However, the Cardinals are 1-4 ATS in their last five games against Big Ten opposition.
Hoosiers Don’t Beat Themselves
Indiana won easily as expected last week by whipping Indiana State 41-7. However, it’s the 23-3 loss to Ohio State in Week 1 which is turning more heads about the Hoosiers.
We're talking flipping the field with James Evans, who just might be nation's best at doing that as — potentially — the nation's best punter. The keys — consistency and work. He has those covered. My story explains … @IndianaFootball #iufb https://t.co/0ifJjo5PAy
— Pete DiPrimio (@pdiprimio) September 6, 2023
The Indiana defense is 15th in the nation, allowing just 236.5 yards per game. They were able to keep an overmatched Indiana team in the game against the ranked Buckeyes. And the Hoosiers are converting 54.8% of third-down plays, 21st in the country.
Louisville vs Indiana Prediction
Louisville is 129th out of 132 FBS schools with a third-down conversion percentage of only 22.7%. Hoosiers punter James Evans leads the country with 53.38 average.
Indiana is 2-0 ATS this season. If the Hoosiers can play a ball-possession game and utilize Evans to win the field-position battle, they can cover in this game.
Louisville vs Indiana Pick: Indiana +10 (-110)
An industry veteran, Bob literally taught the course on the history of sports at Elder College. He has worked as a Sports Columnist for Postmedia, appeared as a guest on several radio stations, was the Vice President of the Society For International Hockey Research in Ontario, and written 25 books.
