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Panthers vs Cardinals Odds, Predictions, Betting Lines, and Picks

Eric Rosales

by Eric Rosales in NFL Football

Updated Nov 13, 2021 · 9:00 AM PST

James Conner running with football
Arizona Cardinals running back James Conner against the San Francisco 49ers during an NFL football game in Santa Clara, Calif., Sunday, Nov. 7, 2021. (AP Photo/Tony Avelar)
  • The NFL-leading Arizona Cardinals are double-digit home favorites vs the struggling Carolina Panthers
  • Sunday Betting Record: 0-0 ML; 2-4 ATS; 1-1 O/U; -4.70 units
  • Read below for odds, analysis and a betting prediction

Injuries are threatening to derail the Arizona Cardinals’ fun-run in the NFL this season.

The Carolina Panthers have inked franchise icon Cam Newton in the hopes of getting their season back on track.

It will make for an interesting matchup in Week 10, as uncertainty dots both rosters, though oddsmakers still have the NFL-best 8-1 Cardinals a 10.5-point favorite at home.

Kickoff goes at 4:05pm ET from State Farm Stadium in Glendale. The game can be seen live on FOX.

Panthers vs Cardinals Odds

Team Moneyline Spread Total
Carolina Panthers +350 +10.5 (-110) O 44.5 (-110)
Arizona Cardinals -475 -10.5 (-110) U 44.5 (-110)

Odds as of  November 13 at DraftKings.

There’s no mistaking where the bettors are leaning: 88% of the bets placed against the spread and on the moneyline are on the Cardinals, while 67% of the public bets are picking the Over.

It’s expected to be a sunny and clear 83 degrees from Glendale when things get underway.

Panthers vs Cardinals Injury Report

The injuries are piling up for the Cardinals, who may have to go another week without starting QB Kyler Murray (ankle) and star receiver DeAndre Hopkins (hamstring). They’re both listed as questionable, and reports indicate they’ll likely be a game-time decision.

Their offensive line is hurting too, as guard Justin Pugh (calf) is questionable and guard Max Garcia (achilles) has already been ruled out. Arizona will start its seventh different O-line combination Sunday. Chase Edmonds (ankle) has also been ruled out, while rookie receiver Rondale More (concussion) is questionable.

On the Carolina side, quarterback Sam Darnold was placed on IR this week for his shoulder injury, and he’s expected to miss anywhere for 4-6 weeks. Also on IR are two parts of their offsensive line: Matt Paradis (torn ACL) and offensive tackle Cameron Irving (calf), who were injured in their Week 9 loss to the Patriots.

They’re dinged up on the defensive side, with linebacker Brian Burns (ankle) listed as questionable following a questionable Mac Jones takedown. Cornerbacks Stanley Thomas-Oliver III (toe) and Rashaan Melvin (hand) are also out against the Cardinals.

The good news is running back Christian McCaffrey, who returned last week after missing the previous five games with a hamstring injury, could be in for his usual workload against Arizona. He gained 106 yards from scrimmage against the Patriots, though only playing 49% of the team’s offensive plays, a number that usually hovers over 90%.

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Cardinals’ Recent Results

Despite missing Murray and Hopkins, the Cardinals still kept the no. 2-ranked offense in the NFL churning, as they whipped the 49ers on the road 31-17.

Backup pivot Colt McCoy did an efficient job filling in, going 22-for-26 for 246 yards and a TD pass.

James Conner, who’s proving to be one of the best offseason pickups of the year, rushed for 96 yards and a pair of scores, while taking a screen pass 45 yards to the house for another.

He leads the NFL with 11 total touchdowns. It was a solid Arizona bounce-back performance after suffering their first loss of the year against the Packers in Week 8.

Panthers’ Recent Results

It’s hard to remember but the Panthers at one point were 3-0 and one of the feel-good stories in the NFL.

They’ve since rattled off losses in five of their last six games, as only a weak conference has them in solid contention for a playoff berth.

Last time out, they were dominated by the New England Patriots 24-6. Darnold was just 16-for-33 for 172 yards and three interceptions, as the offense generated a paltry 240 yards on the day.

PJ Walker will get his first start of the year, though the offensive coordinator Joe Brady told reporters that everything is on the table, with regards to Newton playing.

It seems like a stretch to get Cam immediately under center, but Carolina could unlock a redzone package featuring Newton, who rushed for 11 scores with New England a year ago.

Every little bit helps: Carolina is 29th in the NFL in red zone offense, they’re 26th in scoring at 19 points per game, and they haven’t topped 30 points in a game this season.

Panthers vs Cardinals Trends

Both teams feature pretty impressive defenses. Despite their woes on offense, Carolina’s defense has mostly held up, limiting teams to 20.3 points per game (7th), while they trail only the Buffalo Bills in yards allowed per game.

You don’t get to be the NFL’s current best by not being dominant on both ends: Arizona allows just 17.2 points and 321.0 yards per game this season, both top-4 in the NFL.

The Cardinals are a crisp 7-2 ATS, though they are just 2-2 ATS at home. Carolina is 4-5 ATS, and they are 2-2 ATS on the road.

If you care about recent history, consider that the Panthers have won five in a row against the Cardinals, including a 31-21 win at home last year.

What’s the Best Bet?

I’d wait right up until that 4:05pm ET kickoff to lay a wager, as there are so many uncertainties with key players. That’s a lot of points to get or give up not knowing who’s available.

The one thing we do know is the Cardinals can put up points. Despite Carolina going under the total a whopping 77.8% of the time, their opponent should do most of the heavy lifting to get them there.

Pick: OVER 44.5 points (1.5 units to win 1.86 units)

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