NFL Week 15 Odds – Opening Betting Lines & Spreads for All Games

• NFL Week 15 kicks off with an AFC West clash between the Los Angeles Chargers and Las Vegas Raiders in the TNF game
• The SNF game features a huge AFC showdown between two division leaders in the Baltimore Ravens (North) and Jacksonville Jaguars (South)
• A look at all the opening NFL Week 15 odds can be found below with early predictions

The NFL Week 15 schedule could see the Baltimore Ravens take another big step toward locking up home field for the AFC playoffs. The 10-3 AFC North-leading Ravens are at the 8-5 AFC South-leading Jacksonville Jaguars.

Baltimore’s division rivals the Cleveland Browns beat the Jaguars on Sunday. Meanwhile, the Kansas City Chiefs fell to 8-5 thanks to a 20-17 home-field loss to Buffalo. Win over the Jags and only the AFC East-leading Miami Dolphins (9-3) are standing between Baltimore and home-field advantage.

There’s another dud being served up in the Week 15 TNF game as the Las Vegas Raiders play host to the Los Angeles Chargers in a battle of disappointing 5-8 squads.

Let’s take a look at all the opening betting lines for the NFL’s Week 15 slate.

Opening NFL Week 15 Odds

The NFL odds for Week 15 are showing the San Francisco 49ers as the largest favorites. They are 13.5-point away favorites at the Arizona Cardinals in an NFC West matchup. The 49ers covered as 14.5-point home favorites in a 35-16 win over the Cardinals in Week 4.

Odds as of December 10 at FanDuel Sportsbook. 

For the second week in a row, the Raiders are involved the week’s shortest odds. The TNF game between the Chargers and Raiders is showing Las Vegas as the 1.5-point chalk. The Raiders were 1.5-point home underdogs to the Minnesota Vikings in Week 14. The Dallas Cowboys at Buffalo game is also opening Week 15 with the Bills as 1.5-point home favorites.

The Week 15 total high of 48.5 points features the Cowboys at the Bills. This contest includes the NFL’s #1 scoring offense in Dallas at 32.3 PPG. The smallest total is the 35.5 points assigned to the Atlanta Falcons vs Carolina Panthers game. All together there are six games during Week 15 with totals under 40 points.

The 49ers are favorites in the Super Bowl odds at +300.

Chargers vs Raiders Early Odds & Predictions

The Chargers have scored a total of 13 points over the past two weeks are are 1-1. The Raiders were shut out 3-0 by the Vikings on Sunday. Can you say bet the under? I’ll bet you can.

Los Angeles is 4-2 straight up and against the spread in the past six meetings with Las Vegas. But the Chargers are 0-2 SU and ATS in the last two road games against the Raiders.

Pick: Chargers +1.5 (-115)

Opening Ravens vs Jaguars Odds & Predictions

Jaguars QB Trevor Lawrence played Sunday against Cleveland on a high ankle sprain and was picked off three times during a 31-27 loss.

TYLAN WALLACE ICES THE GAME ❗❗❗ pic.twitter.com/On4jjuacED

— Baltimore Ravens (@Ravens) December 10, 2023

Jacksonville is a dismal 2-4 ATS as a home team this season. The Ravens are 3-2 ATS on the road.

Pick: Ravens -3 (-115)

Expected Week 15 Line Movement

The Cardinals are far from a good team, but they’ve been playing better lately. Coming off their bye week, they are 3-1 ATS over the past four games. Arizona is also 2-1 ATS in the club’s last four home games.

LET'S GO!@budlight x #EasyToCelebrate pic.twitter.com/onfqgsty0z

— San Francisco 49ers (@49ers) December 10, 2023

San Francisco has covered in two successive meetings as the 14.5-point chalk against Arizona. The Cardinals are 3-2 ATS in their past five home games facing the Niners. Don’t be shocked if there’s action on the Cardinals this week that shortens this line.

Pick: Cardinals +13.5 (-110)