Upcoming Match-ups

Week 16 NFL Picks Against the Spread – Early Lines to Target

Robert Duff

by Robert Duff in NFL Football

Updated Dec 20, 2023 · 6:40 AM PST

In the NFL Week 16 ATS picks, the Ravens are 5.5-point road underdogs at the 49ers.
Baltimore Ravens cornerback Brandon Stephens (21) celebrates in the end zone after teammate Baltimore Ravens linebacker Patrick Queen (6) recovered Jacksonville Jaguars quarterback Trevor Lawrence's (16) early fourth quarter fumble.
  • In the Week 16 NFL picks against the spread picks, there are six teams sharing the league lead with ATS marks of 9-5
  • The New England Patriots (3-10-1) are the NFL’s worst ATS team this season
  • All of the Week 16 NFL picks against the spread and early lines to target are outlined in the story below

Entering the Week 16 NFL picks against the spread, looking back to Week 15, it was more like Week 50-50.

Even Steven, You win some, you lose some, you push some.

Darnell Moody’s utter inability to catch a football in the end zone preserved a push for Cleveland against Chicago. Matthew Stafford and the Rams got the job done and covered against the Commanders, who are in command of very little at this stage of the season. However, Tommy DeVito turned back into a pumpkin and the Giants didn’t come anywhere near close to covering at New Orleans.

End result, a 1-1-1 week. Reality check – the chances of a rally to anywhere near something resembling respectability in the NFL ATS picks are as remote as the likelihood of the Denver Broncos looking anything like an NFL team in a road game.

Still, we most motor onward. Something about quitters never winning.

Let’s look ahead to the current NFL odds for the Week 16 ATS picks.

The Tennessee Titans have the Seattle Seahawks right where they want them, as a road favorite. Tennessees is 3-1 ATS this season as a home underdog.

The Baltimore Ravens are getting 5.5 points at San Francisco, and that seems like too many points to pass up. On the other hand, logic may suggest that going with Buffalo -11.5 at the Los Angeles Chargers is giving away too many points. The eye test – LA’s 63-21 loss last week to the Raiders – suggests otherwise.

Now, let’s check out all the best early bets in the Week 16 ATS picks.

Week 16 NFL Picks Against the Spread

Matchup Spread Pick Units Risked
Buffalo Bills vs Los Angeles Chargers BUF-11.5 BUF 1
Seattle Seahawks vs Tennessee Titans SEA-3 TEN 1
Baltimore Ravens vs San Francisco 49ers SF-5.5 BAL 1

Our top NFL ATS picks this week in the table above will feature plays on the Bills, Titans, and Ravens.

Odds as of December 20 at ESPN BET. Check out the ESPN BET promo before betting on NFL Week 16 NFL action. And don’t forget to input the promo code “DIME” when signing up at ESPN BET to get your $250 in bonus bets when you wager at least $10 with your first bet.

ESPN BET


Get a $1,000 Bet Reset at ESPN BET if Your First Bet Loses!

Must manually enter promo code DIME to claim offer.

LOCK IN PROMO
CODE: DIME
CODE: DIME
SIGNUP OFFER
USE PROMO CODE
DIME

FIRST BET RESET UP TO $1,000

GET OFFER NOW

NFL ATS Picks 1: Titans Have Seahawks Number

Along with that 3-1 home ATS record this season, Tennessee is also 4-1 ATS at home in the last five meetings with Seattle. The Titans are 6-1 ATS overall in the last season facing the Seahawks.

The Seahawks though are 1-0 ATS as a road underdog this season. Seattle is also 5-2 ATS as an away team in 2023.

NFL ATS Picks: Tennessee Titans +3 (-120), 1 unit

NFL ATS Picks 2: Bills Keep On Rolling

Sunday’s win over Dallas got Buffalo back on track and the Bills will keep their playoff drive in overdrive as they dismantle a woeful bunch of Chargers. Buffalo is 3-1 ATS over the past four games.

The Chargers are a solid 4-1 ATS in the last five home games facing Buffalo. More recently, LA is 1-5 ATS in the last six games. facing any team.

NFL ATS Picks: Buffalo Bills -11.5 (-110), 1 unit

NFL ATS Picks 3: Ravens Keep It Close At 49ers

Baltimore is an impressive 20-4-1 ATS in the past 25 games the team has been a betting underdog. The Ravens are also 7-2 ATS in their last nine road games.

The 49ers are 16-5 ATS in the club’s past 21 home games. As well, San Francisco is 16-5 ATS in the team’s last 21 MNF games.

NFL ATS Picks: Baltimore Ravens +5.5 (-110), 1 unit

  • NFL ATS record: 15-27-3

Week 16 NFL Picks Against the Spread Quick Picks

  • Rams (-4) vs Saints: The Rams are 6-0 ATS in the last six home games against New Orleans
  • Bengals (-2.5) vs Steelers: Cincinnati is 4-2 ATS in the past six meetings with Pittsburgh
  • Panthers (+5) vs Packers: Carolina is 5-2 ATS in the last seven against Green Bay
  • Texans (+2.5) vs Browns: Houston is 7-1 ATS in the past eight games facing Cleveland
  • Colts (+1) vs Falcons: Indianapolis is 6-1 ATS in the last seven against Atlanta
  • Jets (-3) vs Commanders: Jets are 4-0-1 ATS in the last five when facing Washington
  • Lions (-3.5) vs Vikings: Detroit has covered in five straight against Minnesota
  • Jaguars (+1) vs Buccaneers: Jaguars are 4-1 ATS as a road team this season
  • Dolphins (-1.5) vs Cowboys: Dallas is 0-5 ATS in the past five games as underdogs and 2-7 ATS in the club’s last nine appearances on SNF
  • Cardinals (+4.5) vs Bears: Arizona is 5-1 ATS in the last six meetings with Chicago
  • Patriots (+7) vs Broncos: Denver is a disappointing 2-4 ATS at home this season
  • Raiders (+10) vs Chiefs: Las Vegas is 4-1-1 ATS over the past six games

Author Image