NFL Public Betting & Money Percentages for 49ers vs Cardinals Monday Night Football

• There has been major line movement in the 49ers vs Cardinals public betting splits ahead of their Monday Night Football tilt
• San Fran has gone from an 8-point favorite to -10 after news broke that Kyler Murray will sit
• Get a comprehensive breakdown of the 49ers vs Cardinals public betting splits below

Monday Night Football lands in Mexico this week for the 49ers (5-4) versus Cardinals (4-6) NFC West showdown. This contest has already seen major line movement in the NFL public betting trends today after it was announced that Kyler Murray will not play.

That means Colt McCoy will make his second straight start for Arizona, and the market has reacted accordingly. San Francisco is now a 10-point favorite, up from -8, but the Niners aren’t drawing a ton of interest from bettors at their new, inflated number.

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49ers vs Cardinals ATS Betting Splits

As of early Monday afternoon, the Cardinals are garnering the bulk of the spread money. Arizona is currently drawing 69% of the handle, off of 58% of the spread tickets.

If you’re a big believer in trends, you should run, not walk to your favorite online sportsbook to bet on the Cardinals. Arizona is 22-11-1 against the spread an an underdog in the Kliff Kingsbury era, and 4-1-1 ATS when catching 7 points or more.

Per the 49ers vs Cardinals picks, Arizona has covered against San Francisco in six of their past eight meetings, while Kyle Shanahan and Jimmy Garoppolo have struggled badly to beat the number as favorites.

The Niners under Shanahan have covered just four times in 14 games as 7+ point favorites, and are 2-8-1 ATS in that scenario with Jimmy G under center.

#Cardinals QB Colt McCoy will start on MNF against the #49ers as Kyler Murray will miss his second straight game with a hamstring injury, per @RapSheet pic.twitter.com/M09TiArmwg

— OurSF49ers (@OurSf49ers) November 21, 2022

For anyone who hasn’t seen the Cardinals play without Murray, they may be inclined to fade Arizona. However, number one receiver DeAndre Hopkins is a go, as noted in the 49ers vs Cardinals injury report, and McCoy just led Arizona to an impressive 27-17 victory last week over the defending champion Rams.

San Francisco vs Arizona Total Betting Splits

The spread isn’t the only betting line to see significant movement ahead of Monday Night Football. This game’s total opened at 45 but now sits at 43 or 43.5 depending on where you look.

Unders in primetime games have been a cash cow this season, but pace and style of play are the key factors to pay attention to here. San Francisco operates the 11th-slowest offense in the league and wants nothing more than to run the ball relentlessly.

Colt McCoy Passing Stats as Cardinals Starter

If they could, they’d lean on the ground game almost exclusively, which can bleed the clock dry. That’s why the 49ers vs Cardinals player props are suggesting a fade of two of San Fran’s pass catchers. It’s also why the Niners have seen six of their nine outings fall short of the total.

Arizona prefers to play fast with Murray under center, but note they ran four fewer plays than average with McCoy at the helm last week. McCoy’s four career starts for the Cards have produced an average of 42 points, with only one clearing 44.

49ers vs Cardinals Moneyline Betting Splits

One of those starts was against this same San Francisco team last year, and McCoy shredded the Niners’ defense for 249 yards and a score. The Cards won outright as a 5.5-point underdog, but bettors aren’t expecting a repeat performance tonight.

79% of the moneyline tickets are on San Francisco, along with 65% of the moneyline handle. Arizona has won 11 of the past 14 matchups between these two division rivals and swept the season series versus the 49ers in 2021.

Three of the Niners’ four losses have come as favorites this season, including defeats to Chicago and Denver who each boast a worst record than the Cardinals.

Double-digit underdogs haven’t pulled off too many outright upsets this season, however, they are 7-1 ATS since the start of Week 7, and 1-0 so far in Week 11.