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2021 US Open Men’s Singles Odds & Predictions to Win Every Quarter

Stephanie Myles

by Stephanie Myles in Tennis

Updated Jan 16, 2022 · 2:55 AM PST

Alexander Zverev serving during a tennis match.
FILE - Alexander Zverev, of Germany, serves to Andrey Rublev, of Russia, during the men's single final of the Western & Southern Open tennis tournament in Mason, Ohio, in this Sunday, Aug. 22, 2021, file photo. Zverev is seeded for the U.S. Open, the year's last Grand Slam tennis tournament. Play in the main draw begins in New York on Monday, Aug. 30. (AP Photo/Aaron Doster, File)
  • The top four seeds at the US Open are the overwhelming favorites to win their quarters
  • No. 1 Novak Djokovic, who is aiming to make history in New York, is miles ahead of everyone else
  • We break down each quarter, and pick a best bet and a good long shot.

No Roger Federer.

No Rafael Nadal.

And world No. 1 Novak Djokovic is trying to make history on two fronts. The 34-year-old is looking to complete the Calendar Grand Slam, something that hasn’t been done on the men’s side for more than 50 years.

And, with Federer, Nadal and Djokovic all tied with 20 career Grand Slam titles, winning the 2021 US Open would be the tiebreaker for Djokovic.

US Open Men’s First Quarter Odds

Player Odds
[1] Novak Djokovic (SRB) -700
[6] Matteo Berrettini (ITA) +700
[10] Hubert Hurkacz (POL) +1200
[21] Aslan Karatsev (RUS) +2200
llya Ivashka (BLR) +2200
[14] Alex de Minaur +3500
Kei Nishikori (JPN) +3500
[WC] Jenson Brooksby (USA) +4000
[28] Fabio Fognini (ITA) +5000
Taylor Fritz (USA) +6500

All odds as of August 27th at DraftKings

Anyone but Djokovic? Anyone?

The world No. 1 and tournament favorite took a nice long break to get over his Olympics loss, heal up and recharge after a jam-packed summer.

He has looked in fine form so far in practice. And no one in his potential first three rounds looks fit to trouble him.

Aslan Karatsev, who notoriously beat Djokovic in the final of his own tournament in Belgrade, on clay, has calmed down significantly after an unreal breakout in the first half of the year. Also – this is his debut.

So that leaves No. 6 seed Matteo Berrettini and the underrated Hubert Hurkacz as potential threats.

The problem is, Djokovic would only face one of them in the quarters. The locomotive will be rolling.

Best Bet:  Djokovic (-700)

Long Shot:  Hurkacz (+1200)

US Open Men’s Second Quarter Odds

Player Odds
[4] Alexander Zverev (GER) -110
[13] Jannik Sinner (ITA) +380
[7] Denis Shapovalov (CAN) +500
[9] Pablo Carreño Busta (ESP) +800
Sebastian Korda (USA) +1800
[25] Karen Khachanov (RUS) +2000
[17] Gaël Monfils (FRA) +2000
[31] Alexander Bublik (KAZ) +2800
Lorenzo Musetti (ITA) +2800
[22] Reilly Opelka +4000

Zverev the Favorite, but Could be Tested

Alexander Zverev has plenty of off-court concerns at the moment, which you presume his lawyers are taking care of but still are … out there.

https://twitter.com/AlexZverev/status/1431266563123032073

And he is in what’s arguably the most competitive quarter of the draw.

Zverev’s first test could be No. 31 seed Alexander Bublik who, on a given day, can play lights out.

Denis Shapovalov has had good success in New York. But he’s not playing all that well coming in.

Zverev could get Jannik Sinner in the fourth round.

Young guns Shapovalov, Korda and Opelka and the slightly older Khachanov and Carreño Busta all will be battling for one quarterfinal spot in an exceedingly tough section.

Best Bet:  Zverev (-110)

Long Shot:  Khachanov (+2000)

US Open Men’s Third Quarter Odds

Player Odds
[3] Stefanos Tsitsipas (GRE) +110
[5] Andrey Rublev (RUS)  +350
[12] Félix Auger-Aliassime (CAN) +1400
[18] Roberto Bautista Agut (ESP) +1400
[23] Ugo Humbert (FRA) +1800
Frances Tiafoe (USA) +2200
Nick Kyrgios (AUS) +2200
[26] Cameron Norrie (GBR) +2500
Andy Murray (GBR) +2800
Carlos Alcarez (ESP) +5000

Tsitsipas the Class of the Third Quarter

No. 3 Stefanos Tsitsipas is rather likely to get to the final four out of this quarter.

And that’s so even if he drew former champion Andy Murray in the first round. Once Murray’s friend, the best-of-five format is now his foe.

Rublev vs. Tiafoe could be a fascinating third-round clash. And Auger-Aliassime has a pretty good draw to the fourth round – if he can get his serving act together.

Ugo Humbert could be Tsitsipas’ fourth-round match. And he is NOT a fan of playing the French lefty.

Best Bet:  Rublev (+350)

Long Shot:  Auger-Aliassime (+1400)

US Open Men’s Fourth Quarter Odds

Player Odds
[2] Daniil Medvedev (RUS) -165
[8] Casper Ruud (NOR) +700
[19] John Isner (USA) +1200
[15] Grigor Dimitrov (BUL) +1400
[11] Diego Schwartzman (ARG) +1400
[30] Marin Cilic (CRO) +1600
[24] Dan Evans (GBR) +1600
Kevin Anderson (RSA) +2200
Richard Gasquet (FRA) +15000

Medvedev Should Rule Fourth Quarter

Medvedev is one of the rare players in the draw to have actually reached a US Open final.

YouTube video

The better seeds – Casper Ruud and Diego Schwartzman – are far superior on clay.

No. 19 seed John Isner could make a run. But his body has been barking at him already. And the best-of-five set format will only exacerbate the wear and tear on the 36-year-old’s 6-11 frame. Still, he will give it a major go.

Best Bet: Medvedev (-165)

Long Shot: Isner (+1200)

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